The practice of editing the genes of embryos remains highly controversial and risky, but Origin Genomics founder Cathy Tie argues its a "moral imperative" to address hereditary diseases. When the Chinese scientist He Jiankui announced in 2018 that he had created the first gene-edited babies, the experiment was widely condemned as reckless and premature. It ended with He in prison. But that hasn't stopped the push for gene-edited human embryos, with biotech entrepreneur Cathy Tie arguing that doing so isn't just urgent--it's a "moral imperative." Tie is the 30-year-old founder of Origin Genomics, a company that launched in March with plans to bring gene-edited embryos to IVF clinics.

AI giant Anthropic has announced the discovery of a new enzyme system in bacterial DNA that it said could "represent a new gene editing mechanism" similar to the groundbreaking CRISPR tool. Anthropic said on Wednesday that its signature AI model, Claude, had "autonomously" discovered the system at the prompting of researchers working at the company's recently established biology research lab in San Francisco. CRISPR technology has been credited with advancing the treatment of a range of diseases, including sickle cell disease and cancer. Anthropic, which is at the centre of a vigorous global debate about how to maximise the benefits of AI while mitigating catastrophic risks, said it had not determined the function of the system. It said Claude discovered the system after spending 21 hours searching a large database of DNA sequences. Anthropic CEO Dario Amodei, who has claimed that AI could cure most diseases within five to 10 years, said in a post on X that his company suspects the "molecular machine" could "represent a new gene editing mechanism".

Plus: Anthropic says it has blocked potential plots to build biological weapons. Every year, puts together our 35 Innovators Under 35, a list of some of the brightest and best young minds working across science and technology. This year's honorees include nine people transforming biotech, whose work spans everything from lifesaving innovations to groundbreaking longevity tech. Their innovations include a "reprogramming" therapy that reverses vision loss, tiny brain electrodes inspired by Japanese art, and a personalized gene-editing treatment for a baby with a rare genetic disorder. There are even efforts to design new viruses with generative AI, which (hopefully) will produce new drugs or soak up pollution. Get to know the biotech innovators behind these breakthroughs .

Bootstrap Bio and Manhattan Genomics, which were pursuing gene editing in human embryos to prevent serious disease, have shut down. Two companies that launched last year with plans to create gene-edited babies have already shut down, citing money issues and internal conflict. One of them, Manhattan Genomics of New York, closed abruptly shortly after announcing a team of scientific advisers in October that included a prominent fertility doctor, a data scientist who worked for de-extinction company Colossal Biosciences, and a scientist who pioneered a "three-parent" IVF technique. The other, California-based Bootstrap Bio, said it ceased operations in late 2025, as first reported by Mother Jones. Manhattan Genomics and Bootstrap Bio had ambitions to edit DNA in human embryos with the goal of preventing serious disease in babies.

The development of deep learning approaches for modeling these multifactorial effects of GVs is still in its nascent stages, primarily due to the lack of comprehensive datasets that capture the intricate relationships between GVs and their downstream effects on complex traits.

Among those Robert F. Kennedy Jr. recently named to a federal autism committee are people who tout dangerous treatments and say vaccine manufacturers are "poisoning children." US health secretary Robert F. Kennedy Jr. has filled an autism committee with friends, associates, and former colleagues who believe that autism is caused by vaccines. Autism advocates are now worried the group could pave the way for dangerous pseudoscientific treatments going mainstream. Last week, Kennedy announced an entirely new lineup for the Interagency Autism Coordinating Committee (IACC), a group that recommends what types of autism research the government should fund and provides guidance on the services the autism community requires. The group is typically composed of experts in the area of autism research, along with policy experts and autistic people advocating for their own community.

Predicting critical transitions in complex systems, such as epileptic seizures in the brain, represents a major challenge in scientific research. The high-dimensional characteristics and hidden critical signals further complicate early-warning tasks. This study proposes a novel early-warning framework that integrates manifold learning with stochastic dynamical system modeling. Through systematic comparison, six methods including diffusion maps (DM) are selected to construct low-dimensional representations. Based on these, a data-driven stochastic differential equation model is established to robustly estimate the probability evolution scoring function of the system. Building on this, a new Score Function (SF) indicator is defined by incorporating Schrödinger bridge theory to quantify the likelihood of significant state transitions in the system. Experiments demonstrate that this indicator exhibits higher sensitivity and robustness in epilepsy prediction, enables earlier identification of critical points, and clearly captures dynamic features across various stages before and after seizure onset. This work provides a systematic theoretical framework and practical methodology for extracting early-warning signals from high-dimensional data.

RFK's Overhauled Autism Committee Is Even Worse Than It Looks Kennedy has stacked another HHS panel with his fellow travelers in the anti-vaccine and pseudoscience world. Get your news from a source that's not owned and controlled by oligarchs. Last April, Health and Human Services Secretary Robert F. Kennedy, Jr. promised that his agency would find the cause of autism "by September." That didn't pan out, but this week he appears to be trying again--by stacking a decades-old committee devoted to "innovations in autism research, diagnosis, treatment, and prevention" with his friends and fellow travelers in the anti-vaccine and pseudoscience world. Much like the Centers for Disease Control and Prevention's Advisory Committee on Immunization Practices, which Kennedy overhauled last fall with a full slate of new appointees after firing all the old members, he filled the Interagency Autism Coordinating Committee (IACC), which was first established in 2000 to help set the federal agenda for autism research, with Kennedy's allies in the anti-vaccine movement.

Despite physical limitations, Romito 1 and Romito 2 likely lived into adulthood about 12,000 years ago. Breakthroughs, discoveries, and DIY tips sent six days a week. In 1963, paleoarchaeologists working in southern Italy discovered a unique and puzzling burial scene within an ancient cave known as Grotta del Romito. Inside the cavern, researchers excavated the bodies of two Paleolithic individuals buried in an embrace over 12,000 years ago with no signs of outward trauma. Designated Romito 1 and Romito 2, both subjects had clearly shortened limbs, each with a respective height of around 4.75 and 3.6 feet tall.